Dear Annie:

Today I mourn the loss of a dear friend. She was vibrant, energetic and full of life, but on a crisp autumn afternoon, she committed suicide.

I do not know what transpired in the final hours of her life, but I do know she had been under a tremendous amount of stress. I have been in the health care profession for many years and am ashamed to say I missed the warning signs.

I ask your readers to take the time to really listen to others and be aware of the warning signs of depression.-Michelle in Greensboro, N.C.

Dear Michelle:

Our condolences on your terrible loss. According to the National Institutes of Health, symptoms of depression include: persistent sad or anxious feelings; feelings of hopelessness and/or pessimism; feelings of guilt, worthlessness and/or helplessness; irritability, restlessness; loss of interest in activities or hobbies once pleasurable; fatigue and decreased energy; difficulty concentrating in making decisions; insomnia, early-morning wakefulness or excessive sleeping; overeating or appetite loss; thoughts of suicide; persistent aches or pains, headaches, cramps or digestive problems that do not ease even with treatment.

It is easy to miss the signs if you aren't looking because your friend or family member seems fine, but depression increases during the winter months. Please tell your loved ones how much they mean to you.

vibrant:活泼的

crisp：涼爽的;清爽的

to transpire：发生

tremendous：沈重的

condolence：哀悼，慰问

persistent：持续的，不断地

pessimism：悲观主义

irritability：易怒

insomnia：失眠